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1.
Ligang Yu Yong Li Yukun Yang Caixia Guo Meiping Li 《International Journal of Food Science & Technology》2022,57(7):4646-4655
This study investigated the inhibitory effects of curcumin and piperine on fluorescent advanced glycation end products (fAGEs) formation in a bovine serum albumin (BSA)–fructose model. Model systems of BSA and fructose were prepared, and curcumin or piperine was added. fAGEs and BSA oxidation product (dityrosine, kynurenine and N'-formylkynurenine) contents were determined. The results showed that fAGEs content decreased with increasing concentration of curcumin and piperine (P < 0.05). Addition of curcumin and piperine at 160 µg mL−1 could inhibit fluorescent AGEs by 100% and 93% respectively. Dityrosine and N'-formylkynurenine contents decreased as curcumin and piperine concentration increased (P < 0.05). Furthermore, the result of principal component analysis indicated that curcumin and piperine markedly impeded BSA oxidation, resulting in a lower level of fAGEs in model systems. Therefore, adding curcumin and piperine may facilitate reduced fAGEs levels in BSA–fructose model. 相似文献
2.
Qiaozhi Zhang Yanbo Wang Linglin Fu 《Comprehensive Reviews in Food Science and Food Safety》2020,19(5):2559-2587
Dietary advanced glycation end products (dAGEs) are complex and heterogeneous compounds derived from nonenzymatic glycation reactions during industrial processing and home cooking. There is mounting evidence showing that dAGEs are closely associated with various chronic diseases, where the absorbed dAGEs fuel the biological AGEs pool to exhibit noxious effects on human health. Currently, due to the uncertain bioavailability and rapid renal clearance of dAGEs, the relationship between dAGEs and biological AGEs remains debatable. In this review, we provide the most updated information on dAGEs including their generation in processed foods, analytical and characterization techniques, metabolic fates, interaction with AGE receptors, implications on human health and reducing strategies. Available evidence demonstrating a relevance between dAGEs and food allergy is also included. AGEs are ubiquitous in foods and their contents largely depend on the reactivity of carbonyl and amino groups, along with surrounding condition mainly pH and heating procedures. Once being digested and absorbed into the circulation, two separate pathways can be involved in the deleterious effects of dAGEs: an AGE receptor‐dependent way to stimulate cell signals, and an AGE receptor‐independent way to dysregulate proteins via forming complexes. Inhibition of AGEs formation during food processing and reduction in the diet are two potent approaches to restrict health‐hazardous dAGEs. To elucidate the biological role of dAGEs toward human health, the following significant perspectives are raised: molecular size and complexity of dAGEs; interactions between unabsorbed dAGEs and gut microbiota; and roles played by concomitant compounds in the heat‐processed foods. 相似文献
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为了解决大采高综放工作面回风侧端头顶板控制问题,针对马道头矿8211工作面的地质情况,通过对回风顺槽超前注浆加固,提高超前支护范围和支护强度,并对回风侧端头三角区煤壁和顶板进行化学浆加固的技术方案,有效控制了顺槽超前区围岩变形和工作面回风侧端头三角区煤壁片帮,保证了工作面端头区顶板安全。 相似文献
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为了提高综采工作面端头超前应力区顶板稳定性,降低顶板支护费用,对8309工作面端头应力区提出了耦合让均压支护技术,控制了端头应力区顶板下沉、破碎现象,可降低支护成本费用320元/m。 相似文献
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三峡船闸深槽开挖与锚固工程量大,工期紧,施工强度高,施工难度大。因此,合理的施工程序有利于边坡稳定和施工,是快速和高质量施工的关键。分析了永久船闸直立墙基坑开挖与锚固施工程序的复杂性和进行研究的必要性。介绍了设计阶段研究船闸开挖与锚固的施工程序。对施工过程中研究施工程序时考虑的因素,研究的主要内容以及实际采用的施工程序作了简要的分析,归纳和总结。 相似文献
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Xu You-heng Dong Li-yun Huang Dong-qun Fudan University Shanghai P. R. China 《水动力学研究与进展(B辑)》1998,(3)
In this paper,the oscillation amplitude of the free end of a group of threecylinders are studied.The three cylinders are erected at the vertices of an equilateral trian-gle,and three arrangements are made in this study.One of the three cylinders is served asa working cylinder which is mounted by a flexible cantilever and two accelerometers areattached on the free end in two directions.The results of the three-cylinder arrangementare compared with those of two cylinders in tandem/side-by-side arrangement in the samecondition.The experimental results show that the rear cylinder of a group of three cylin-ders is affected more seriously than that of the corresponding two cylinders in the contrastarrangement.The main direction of oscillation is changed.The transversal oscillation isstronger than the longitudinal oscillation in the three-cylinder arrangement.On the con-trary,the transversal oscillation is much weaker than the longitudinal oscillation in two-cylinder arrangement.The largest transversal oscillat 相似文献
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介绍燕山石化公司为扩大1Mt/a中压加氢改质装置的原料来源,改用大庆减二线油和重油催化裂化柴油组成的混合料开工投产的经验以及装置初期的运行条件。中压加氢改质技术可以生产优质柴油和蒸汽裂解制乙烯的原料,还可增产喷气燃料。 相似文献